There are many natural active polysaccharides in marine σorganisms, which can be divided into three categories according to their sources: seaweed polysaccharides, marine animal polysaccharides and marine microbial polysacch♣arides. Many of them have significant antitumor activity, some of them have the value of industri al production, and the others are expected to be developed into new drugs. With the rapid✔ development of modern science and technology and medicine, people have achieved extraction of polysaccharides from marine organi≥sms, which has realized industrialization. However, the t raditional technology and equipment can not meet the r₽equirements of extraction, separation, purification and concentration of polysacchari des from marine organisms, and the yield can not be improved, let alone ensure the activity of ef♣fective components. Therefore,
Guo Chu Technology (Xiamen) Co., Ltd., has effectively utilized various
membrane separation technologies of the company, successfully developed a variety of new t↓echnologies for the extraction of marine biological polysaccharides, and can provide a complet≤e set of process solutions.
Application of Membrane Technology in the Extraction Process of Chondroitin Sulfate by Guo Chu Technology (Xiamen) Co., Ltd.
Chondroitin sulfate is a kind of mucopolysaccharide, which can be used to re←gulate the concentration of anions in human body, and combi®ne with some substances to regulate the immunity of the bo•dy. It can effectively prevent the infection of bacteria and viruses, and has the functions of anticoagulant, inhibitio&n of thrombosis, and regulation of lipid metabolism.
Traditionally, chondroitin sulfate was purified by way of ‘Water Extraction and Alcohol Precipitation’ based on the property that cartilγage sulfate was insoluble in ethanol solution. In the production process of chonεdroitin sulfate, 60% ethanol solution produced after alcohol pr£ecipitation was recovered by ethanol recovery tower, and the mother liquor $containing animal chondroprotein was produced.
Since animal cartilage hydrolysate contains a lot of protein and other€ macromolecular impurities, the precipitation effect of alcohol p↓recipitant will be reduced when the feed liquid is chemically ex tracted, as during the precipitation of chondroitin sulfate by the precipit ant, impurities such as animal proteins and polypeptides wil∏l also be precipitated, the useful components in hydrolysate can not be fully precipitated. Furthermore, due to the impuri↔ties such as proteins in the precipitated mixture, the re-separation process beαcomes very difficult, which increases the difficulty and cost of post-process.
Based on years of experience in membrane application, Guo Chu Technology has put forward soluti₩ons:
For protein and other macromolecular impurities, ultrafiltration system is used to remove macromole™cular protein impurities, and then the feed liquid is pre-conc♥entrated by nanofiltration system to reduce the alcohol consumption and save the cost.
At the same time, for the mother liquid after alcohol recovery, nanofiltration system wa<s used to concentrate and recover animal protein, w hich could avoid the damage of animal protein by traditional eva poration method through high-temperature evaporation concentrator, so that the animalφ protein could be used as animal feed, and the discharged wastewater could meet the environme∑ntal protection standard.
Application of Membrane Technology in the Extraction Process of Sea Cucumber Polysaccharide by Guo Chu Technology (Xiamen) Co., Ltd.
Sea cucumber polysaccharide is an important component in the body €wall of sea cucumber, and its content accounts for more than 6% of the total organic matter ×in dry sea-cucumber. There are two kinds of polysaccharides∞ in the body wall of sea cucumber. The first is sea cucumber glycosaminoglycan or mucopolysacch♦aride, which is a branched heteropolysaccharide composed♠ of D-N-acetylgalactosamine, D-glucuronic acid and L-fucose, with a relative molecular φweight of 40000-50000; The other is sea cucumber fuco±idan, which is a straight-chain homogeneous polysaccharide composed of L-fucose, with a relative ★molecular weight of 80000-100000. Although the compos→ition of glycosyl groups of these two polysaccharides is different, they both have certain hydro>xyl groups in their saccharic chains which are sulfated, and ∑the content of sulfate groups in both polysaccharides is about 32%. GCM-C microfiltration device ≠adopted by Guo Chu Technology (Xiamen) Co., Ltd., can effect$ively remove macromolecular colloid, suspended solids and other impurities in sea cucumber poλlysaccharide, and obtain clear and transparent polysaccharide solutioδn. Then, sea cucumber polysaccharide can be effectively concentr≈ated through GCM-C nanofiltration device. This process has been applied in a mature ¶way.
Application of Membrane Technology in the Extraction Process of Seaweed Polysaccharide by Guo Chu Technology (Xiamen) Co., Ltd.
There are two kinds of bioactive substances in seaweed: One is the sub§stance with low molecular weight, which can directly or indεirectly affect the metabolism of the body after absorption, mainly i£ncluding halogenated compounds, terpenoids, bromophenols, hyd✔roquinone, seaweed tannin, and laminine; the other is the intercellular viscous poly™saccharides that are difficult to be digested and absorbed, mainly including alg₹inic acid, fucoidin, sulfate polysaccharide, agar and carrageenan in red algae.
Seaweed polysaccharides mainly come from kelp, sargassum ★fusiforme, giant algae, bladder wrack and so on. Seaweed polysaccharides mainly include alg$in, fucoidin and alginate starch. The crude algin, fucoidin and> alginate starch separated from kelp are all white and yellowish powder×. The purified sodium alginate was white filamentous; Fucoidin is milky white powder; Both o•f them are soluble in water, insoluble in ethanol, acetone, chlo♣roform and other organic solvents.
GCM-C microfiltration device adopted by Guochu Technology (Xiamen) Co., Ltd., can §effectively remove macromolecular colloid, suspended solids and ot₹her impurities in seaweed polysaccharide, and obtain clear and trans÷parent polysaccharide solution. Then, seaweed polysacc∞haridecan be effectively concentrated through GCM-C nanofiltration device. This process has been apφplied in a mature way.
Application of Membrane Technology in the Extraction Process of Chitosan by Guo Chu Technology (Xiamen) Co., Ltd.
Chitosan, also known as deacetylation chitin, is obtained by deacetylation of chitin wi¥dely existing in nature. Its chemical name is Polyglucosamine (1-4)-2♣-Amino-B-D glucose. This kind of natural polymer has aroused a b♦road attention by various industries for its excellent properties such as₽ biological functionality and compatibility, blood compatibility,ε safety and microbial degradation. Its application research h≥as made great progress in the fields like medicine, food, chemical industry, cosmetics, w ater treatment, metal extraction and recovery, bioc hemical and biomedical engineering. In medical field, the∏ effect of chitosan on reducing blood lipid and blood sugar has been reported.
Due to the high viscosity of chitosan, there are man♦y problems with the traditional evaporation process for chitos§an concentration, and there has been no effective means to classify chitosan of dπifferent molecular weight. By adopting GCM-S ultrafiltration device,
Guo Chu Technology (Xiamen) Co., Ltd. has successfully retained and concentrated chitosan to more than 5% concentration degree. The ✘process requires no heating and no phase transformation, and t•he concentrate can be directly used in the end products. The dialysate contains a< large number of small molecular polysaccharides. Thro§ugh GCM-S nanofiltration device, the small molecule chitosan ca♥n be effectively recovered and concentrated, achieving the classifiΩcation of chitosan productsand creating greater value.
The application of membrane separation technology in marine biological polysaccharide extraction related industries has a series of advantages, such as improving product quality, simplifying production proces™s, reducing energy consumption and so on. Due to t♦he increasing demand for marine biological polysaccharide extract in the global market and ✘the demand for high-quality marine biological polysacchδaride, membrane technology will also be widely used in the marine biological polysaccharide extraction industry.
Guo Chu Technology (Xiamen) Co., Ltd. has rich experience in the application of membrane separation technology in the extracti₽on of marine biological polysaccharides, and can provide users with comprehensive solutions of¥ new and effective separation technology.
