Antibiotic is divided into 5 categories in general: β- lactam anti←biotics (such as penicillin), amino acid glycoside antibiotics, macrolides anti∞biotics (such as erythrocin and spiramycin), tetracyclic lact"one antibiotics (such as tetracycline) and polypeptide antibiotics (such as vancomycin), and• the relative molecular mass is within 300~1200, which is βcommonly found in liquids. The methods of extraction from fermentation broth mainly inc≥lude adsorption method, solvent extraction method, ion exchange method and precipitati™on method, but these processes are often very complicated, time-consuming, need> to consume a large amount of raw materials with high✔ energy consumption, and antibiotics are susceptible to inactivation durin₩g the long extraction with low product recovery rate, serious waste water pollution, difficulty of processing and low concentration of antibiotics in the obt ained solution.
With the continuous innovation of technologies, membrane$ separation technology and continuous moving bed technology have gradually replaced the traditio<nal plate and frame filtration, fixed bed and other devices in the process of anti≤biotic extraction, which effectively solves the problems of p↑oor quality of antibiotics, backward processes and poor↔ production environments. Membrane separation technology and continuous moving ≠bed technology have been widely used in the production of many antibiotics, such as peniciπllin, cephalosporin, erythromycin and colistin sulfate.
Membrane separation technology and continuous moving bed tech®nology have been widely used in the antibiotic industry:
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Ceramic membrane and flat membrane is used to replace the tradi≈tional filtration methods to clarify the fermentation liquor,≠ improve the quality of filtrate and reduce the resin pollution and s←olvent dosage in the later process
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The hyperfiltration membrane is used to rem≠ove protein and decoloration and improve quality
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The nanofiltration membrane is used to concentrate antibiotics, repl$ace or shorten the evaporation and concentration time; increase crysta£llization yield or reduce evaporation loss
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Continuous moving beds are used to replace the fixed beds, save resin dosage and red↔uce unit consumption
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The membrane technology is used to recycle var§ious mother liquors, waste liquids and reclaimed water reuse
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Technical characteristics:
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High yield of active ingredients, w☆hich can improve 5～12% compared with the traditional filtration method;∏
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High separation precision, less impur↕ity content in the permeate, clear and transparent, and the difficulty of su≠bsequent processing which can be reduced;
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High concentration multiple, greatly reduce the application amount ↔of water, less waste water discharge;
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Long continuous working hours, simp★le and efficient regeneration;
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Long service life of membrane elements;
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The service life of the matching ion exchange resin÷ and macroporous adsorption resin can be prolonged σby 2~3 times;
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The price performance ratio is higher than all the effective separation met hods;
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Form a membrane integrated system, which greatlyσ improves the extraction efficiency.
The kinetic equation of membrane fouling formation is established to solve the problem of membrane fouling and develop a special membrane cleaning an÷d regeneration method; effectively solve the degradation and deacti vation problems of target products; the conventional mat≠erial washing methods are changed to effectively improve permeation flux ¶and antipollution performance, reduce the amount of wat™er and improve the yield of target products; the solution of these problems achieves the ✔widely application of ceramic membrane in fermentation indu•stry.
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